| Protein ID | Gene Name | Functional Assingment | Protein Expression and Mutation Evidence | Associated Reactions in Metabolic Model | |||||||||||||||||||
| Microaerophilic Protein Expression | Microaerophilic Mutation Data | Anaerobic Protein Expression | |||||||||||||||||||||
| Candidate' proteins | Match AER | High confidence proteins | Match AER | Essential gene[1] | Match MA | Non-essential gene | Candidate' proteins | High confidence proteins | |||||||||||||||
| HI0001 | gapA | glyceraldehyde-3-phosphate dehydrogenase (gapdH) | X | Match | X | Match | X | Match | X | X | T3P1 + PI + NAD <-> NADH + 13DPG | ||||||||||||
| HI0006m | fdxG | Formate dehydrogenase large subunit | X | Match | X | X | FOR + Q -> QH2 + CO2 +2 HEXT | ||||||||||||||||
| HI0007 | fdxH | formate dehydrogenase, beta subunit (fdxH) | X | FOR + Q -> QH2 + CO2 +2 HEXT | |||||||||||||||||||
| HI0008 | fdxI | formate dehydrogenase, gamma subunit (fdxI) | X | X | FOR + Q -> QH2 + CO2 +2 HEXT | ||||||||||||||||||
| HI0022 | citF | citrate lyase, alpha chain (citF) | X | Match | X | Match | X | X | CIT -> AC + OA | ||||||||||||||
| HI0023 | citE | citrate lyase, beta chain (citE) | X | Match | X | Match | X | Match | X | X | CIT -> AC + OA | ||||||||||||
| HI0047 | eda | 4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolase (eda) | X | Match | X | X | 2KD6PG -> T3P1 + PYR | ||||||||||||||||
| HI0049 | kdgK | 2-dehydro-3-deoxygluconokinase (kdgK) | X | X | KDG + ATP -> 2KD6PG + ADP | ||||||||||||||||||
| HI0055 | uxuA | mannonate dehydratase (uxuA) | X | Match | X | MANNAT -> KDG | |||||||||||||||||
| ALTRNT -> KDG | |||||||||||||||||||||||
| HI0058 | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase (kdsB) | X | KDO + CTP -> PPI + CMPKDO | |||||||||||||||||||
| HI0064 | folK | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine-pyrophosphokinase (folK) | X | AHHMP + ATP -> AMP + AHHMD | |||||||||||||||||||
| HI0075 | nrdD | anaerobic ribonucleoside-triphosphate reductase (nrdD) | X | Match | X | CTP + RTHIO -> DCTP + OTHIO | |||||||||||||||||
| UTP + RTHIO -> OTHIO + DUTP | |||||||||||||||||||||||
| ATP + RTHIO -> DATP + OTHIO | |||||||||||||||||||||||
| GTP + RTHIO -> DGTP + OTHIO | |||||||||||||||||||||||
| HI0085 | ldhA | D-lactate dehydrogenase, fermentative (ldhA) | X | X | NAD + LAC <-> PYR + NADH | ||||||||||||||||||
| HI0086 | metB | cystathionine gamma-synthase (metB) | X | Match | X | Match | X | X | OAHSER + CYS -> AC + LLCT | ||||||||||||||
| OSLHSER + CYS -> SUCC + LLCT | |||||||||||||||||||||||
| HI0087 | thrC | threonine synthase (thrC) | X | Match | X | Match | X | Match | X | X | PHSER -> PI + THR | ||||||||||||
| HI0088 | thrB | homoserine kinase (thrB) | X | HSER + ATP -> ADP + PHSER | |||||||||||||||||||
| HI0089 | thrA | aspartokinase I / homoserine dehydrogenase I (thrA) | X | Match | X | ASP + ATP <-> ADP + BASP | |||||||||||||||||
| ASPSA + NADPH <-> NADP + HSER | |||||||||||||||||||||||
| HI0102 | dapE | succinyl-diaminopimelate desuccinylase (dapE) | X | Match | X | X | NS26DP -> SUCC + D26PIM | ||||||||||||||||
| HI0122 | metC | cystathionine beta-lyase (metC) | X | LLCT -> HCYS + PYR + NH3 | |||||||||||||||||||
| HI0123 | pgsA | phosphatidylglycerophosphate synthase (pgsA) | X | CDPDG + GL3P <-> CMP + PGP | |||||||||||||||||||
| HI0124 | ppa | inorganic pyrophosphatase (ppa) | X | Match | X | Match | X | Match | X | X | PPI -> 2 PI | ||||||||||||
| HI0132 | udk | uridine kinase (udk) | X | Match | X | URI + GTP -> GDP + UMP | |||||||||||||||||
| HI0133 | dcd | deoxycytidine triphosphate deaminase (dcd) | X | DCTP -> DUTP + NH3 | |||||||||||||||||||
| HI0140 | nagA | N-acetylglucosamine-6-phosphate deacetylase (nagA) | X | X | X | Match | NAGP -> GA6P + AC | ||||||||||||||||
| HI0141 | nagB | glucosamine-6-phosphate isomerase (nagB) | X | Match | X | X | Match | X | GA6P -> F6P + NH3 | ||||||||||||||
| HI0142 | nanA | N-acetylneuraminate lyase (nanA) | X | Match | X | Match | SE | X | X | SLA -> PYR + NAMAN | |||||||||||||
| HI0144 | glk | glucose kinase, putative | X | Match | X | X | GLC + ATP -> G6P + ADP | ||||||||||||||||
| HI0155 | fabG | 3-ketoacyl-acyl carrier protein reductase (fabG) | X | X | Match | ACACP +5 MALACP +10 NADPH -> 10 NADP + C120ACP +5 CO2 +5 ACP | |||||||||||||||||
| ACACP +6 MALACP +12 NADPH -> 12 NADP + C140ACP +6 CO2 +6 ACP | |||||||||||||||||||||||
| ACACP +6 MALACP +11 NADPH -> 11 NADP + C141ACP +6 CO2 +6 ACP | |||||||||||||||||||||||
| ACACP +7 MALACP +14 NADPH -> 14 NADP + C160ACP +7 CO2 +7 ACP | |||||||||||||||||||||||
| ACACP +7 MALACP +13 NADPH -> 13 NADP + C161ACP +7 CO2 +7 ACP | |||||||||||||||||||||||
| ACACP +8 MALACP +15 NADPH -> 15 NADP +1 C181ACP +8 CO2 +8 ACP | |||||||||||||||||||||||
| HI0156 | fabD | malonyl CoA-acyl carrier protein transacylase (fabD) | X | Match | X | Match | X | MALCOA + ACP <-> MALACP + COA | |||||||||||||||
| HI0157 | fabH | beta-ketoacyl-ACP synthase III (fabH) | X | Match | X | X | Match | X | ACCOA + ACP <-> ACACP + COA | ||||||||||||||
| HI0160 | psd | phosphatidylserine decarboxylase proenzyme (psd) | X | PS -> PE + CO2 | |||||||||||||||||||
| HI0161 | gor | glutathione reductase (gor) | X | Match | X | Match | X | X | X | NADPH + OGT <-> NADP + RGT | |||||||||||||
| HI0179 | pflA | pyruvate formate-lyase activating enzyme (act) | X | X | Match | PYR + COA -> ACCOA + FOR | |||||||||||||||||
| HI0180 | pflB | formate acetyltransferase (pfl) | X | Match | X | Match | X | X | PYR + COA -> ACCOA + FOR | ||||||||||||||
| HI0181 | focA | formate transporter | X | Match | X | Match | X | FORxt <-> FOR | |||||||||||||||
| HI0185 | adhC | alcohol dehydrogenase, class III (adhC) | X | X | LACAL + NAD <-> LLAC + NADH | ||||||||||||||||||
| GLAL + NADH <-> GL + NAD | |||||||||||||||||||||||
| HI0189 | gdhA | glutamate dehydrogenase (gdhA) | X | Match | X | X | AKG + NH3 + NADPH <-> GLU + NADP | ||||||||||||||||
| HI0194 | menE | O-succinylbenzoate--CoA ligase (menE) | X | OSB + ATP + COA -> OSBCOA + AMP + PPI | |||||||||||||||||||
| HI0196 | aroC | chorismate synthase (aroC) | X | Match | X | Match | X | Match | X | X | 3PSME -> PI + CHOR | ||||||||||||
| HI0199 | msbB | lipid A biosynthesis (kdo)2-(lauroyl)-lipid IVA acyltransferase (msbB) | X | KDOLIPIVP + C140ACP + C120ACP -> LIPA +2 ACP | |||||||||||||||||||
| HI0206 | ushA | 5'-nucleotidase, putative | X | Match | X | Match | X | X | X | DUMP -> DU + PI | |||||||||||||
| DTMP -> DT + PI | |||||||||||||||||||||||
| DAMP -> DA + PI | |||||||||||||||||||||||
| DGMP -> DG + PI | |||||||||||||||||||||||
| DCMP -> DC + PI | |||||||||||||||||||||||
| CMP -> CYTD + PI | |||||||||||||||||||||||
| AMP -> PI + ADN | |||||||||||||||||||||||
| GMP -> PI + GSN | |||||||||||||||||||||||
| IMP -> PI + INS | |||||||||||||||||||||||
| XMP -> PI + XTSN | |||||||||||||||||||||||
| UMP -> PI + URI | |||||||||||||||||||||||
| HI0207 | aroK | shikimic acid kinase I (aroK) | X | Match | X | X | SME + ATP -> ADP + SME5P | ||||||||||||||||
| HI0208 | aroB | 3-dehydroquinate synthase (aroB) | X | X | Match | 3DDAH7P -> DQT + PI | |||||||||||||||||
| HI0211 | pgpB | H. influenzae predicted coding region HI0210 | X | PGP -> PI + PG | |||||||||||||||||||
| HI0212 | pgpB (changed from ribA) | phosphatidylglycerophosphatase B (pgpB) | X | X | Match | PGP --> PI + PG (Changed from GTP -> D6RP5P + FOR + PPI) | |||||||||||||||||
| HI0221 | guaB | inosine-5'-monophosphate dehydrogenase (guaB) | X | Match | X | Match | X | X | IMP + NAD -> NADH + XMP | ||||||||||||||
| HI0222 | guaA | GMP synthase (guaA) | X | Match | X | Match | X | Match | X | X | XMP + ATP + GLN -> GLU + AMP + PPI + GMP | ||||||||||||
| HI0225 | nhaB | Na+/H+ antiporter (nhaA) | X | Match | X | NAxt <-> NA + HEXT | |||||||||||||||||
| HI0226 | brnQ | branched chain amino acid transport system II carrier protein (brnQ) | X | LEUxt + HEXT <-> LEU | |||||||||||||||||||
| ILExt + HEXT <-> ILE | |||||||||||||||||||||||
| VALxt + HEXT <-> VAL | |||||||||||||||||||||||
| HI0255 | dapA | dihydrodipicolinate synthetase (dapA) | X | Match | X | Match | X | Match | X | X | ASPSA + PYR -> D23PIC | ||||||||||||
| HI0265 | folB | dihydroneopterin aldolase, putative | X | DHP -> AHHMP + GLAL | |||||||||||||||||||
| HI0268 | murB | UDP-N-acetylenolpyruvoylglucosamine reductase (murB) | X | Match | X | Match | X | X | UDPNAGEP + NADPH -> UDPNAM + NADP | ||||||||||||||
| HI0272 | pyrE | orotate phosphoribosyltransferase (pyrE) | X | OROA + PRPP <-> PPI + OMP | |||||||||||||||||||
| HI0280 | udp | uridine phosphorylase (udp) | X | Match | X | Match | X | X | X | URI + PI <-> URA + R1P | |||||||||||||
| HI0283 | menD | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase (menD) | X | X | Match | AKG + TPP -> SSALTPP + CO2 | |||||||||||||||||
| ICHOR + SSALTPP -> PYR + TPP + SHCHC | |||||||||||||||||||||||
| HI0285 | menF | menaquinone-specific isochorismate synthase (menF) | X | X | Match | CHOR -> ICHOR | |||||||||||||||||
| HI0287 | mtr | tryptophan-specific transport protein (mtr) | X | X | TRPxt + HEXT <-> TRP | ||||||||||||||||||
| HI0288 | sdaA | L-serine deaminase (sdaA) | X | X | SER -> PYR + NH3 | ||||||||||||||||||
| THR -> OBUT + NH3 | |||||||||||||||||||||||
| HI0289 | sdaC | serine transporter (sdaC) | X | Match | X | SERxt + HEXT <-> SER | |||||||||||||||||
| HI0307 | proC | pyrroline-5-carboxylate reductase (proC) | X | Match | X | GLUGSAL + NADPH <-> PRO + NADP | |||||||||||||||||
| HI0323 | gloA | lactoylglutathione lyase (gloA) | X | Match | X | Match | X | X | MTHGXL + RGT -> LCTGT | ||||||||||||||
| HI0335 | dgkA | diacylglycerol kinase (dgkA) | X | X | Match | DGR + ATP -> ADP + PA | |||||||||||||||||
| HI0349 | adk | adenylate kinase (adk) | X | Match | X | Match | X | X | X | ATP + AMP <-> 2 ADP | |||||||||||||
| DAMP + ATP <-> ADP + DADP | |||||||||||||||||||||||
| HI0351 | galE | UDP-glucose 4-epimerase (galE) | X | UDPGAL <-> UDPG | |||||||||||||||||||
| HI0390.1 | fadD | long chain fatty acid coenzyme A ligase (fadD) | ATP + C120 + COA <-> AMP + PPI + C120COA | ||||||||||||||||||||
| ATP + C140 + COA <-> AMP + PPI + C140COA | |||||||||||||||||||||||
| ATP + C141 + COA <-> AMP + PPI + C141COA | |||||||||||||||||||||||
| ATP + C160 + COA <-> AMP + PPI + C160COA | |||||||||||||||||||||||
| ATP + C161 + COA <-> AMP + PPI + C161COA | |||||||||||||||||||||||
| ATP + C181 + COA <-> AMP + PPI + C181COA | |||||||||||||||||||||||
| HI0401 | fadL | long-chain fatty acid transport protein (fadL) | X | Match | X | X | X | C120xt -> C120 | |||||||||||||||
| C140xt -> C140 | |||||||||||||||||||||||
| C141xt -> C141 | |||||||||||||||||||||||
| C160xt -> C160 | |||||||||||||||||||||||
| C161xt -> C161 | |||||||||||||||||||||||
| C181xt -> C181 | |||||||||||||||||||||||
| HI0406 | accA | acetyl-CoA carboxylase, carboxyl transferase (accA) | X | Match | X | x | Match | X | ACCOA + ATP + CO2 <-> MALCOA + ADP + PI | ||||||||||||||
| HI0415 | thiM | hydroxyethylthiazole kinase | X | X | THZ + ATP -> THZP + ADP | ||||||||||||||||||
| HI0416 | thiD | phosphomethylpyrimidine kinase (thiD) | |||||||||||||||||||||