BIATECH has recently developed a spectral quality assessment software tool, named SPEQUAL, to be used in HTP proteome studies. SPEQUAL is described in the paper:

S. Purvine, N. Kolker, & E. Kolker, Spectral quality assessment for high throughput tandem mass spectrometry proteomics, OMICS, 2004, 8(3), 255-265.

Also we developed CHASTE program that estimates charge state for low mass accuracy ion-trap mass spectrometers (i.e. LCQ or LTQ). Pre-processing by this program can greatly reduce the number of redundant charge state searches of the same MS/MS spectra done by database search programs such as SEQUEST, Mascot or X!tandem. Chaste is described in the paper:

Hogan JM, Higdon R, Kolker N, Kolker E. Charge state estimation for tandem mass spectrometry proteomics.

SPEQUAL, CHASTE are available FREE of CHARGE to nonprofit, educational, academic, and industrial researchers.

To download the software, please print the request page. A signature is required from the lab/department head, group leader, or manager. Please also add
your name, affiliation, and exact address, including e-mail, phone, and fax.
Mail or fax it to us at:

Seattle Childrens's Hospital

Research Institute

1900 Ninth Avenue,
Seattle
WA 98101-1304
[FAX] (206) 9877175

ATTN: Natali Kolker

If you have any questions about these data, please click here.

Proteome - proteins expressed by a cell or organ at a particular time and under specific conditions – is analyzed by Proteomics - the study of the full set of proteins encoded by a genome. The leading proteomics approach to date employed by BIATECH is mass spectrometry.